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Following administration the DDSs liberate the active ingredients and subsequently the bioactive molecules are transported across various biological barriers to reach the site of action. An introduction to fast dissolving oral thin film drug delivery systems.
Introduction Amongst the various routes of drug delivery oral route is the most preferred to the patient.
Introduction of oral drug delivery system. The term oral drug delivery also referred to as peroral delivery refers to taking a dosage form by mouth for local action or systemic absorption at any point along the gastrointestinal GI tract. The human GI tract is an organ composed of the oral cavity pharynx esophagus stomach and. Controlled Release Oral Drug Delivery System Controlled drug delivery is one which delivers the drug at a predetermined rate for locally or systemically for a.
13 INTRODUCTION Oral drug delivery is widely used in pharmaceutical field to treat the diseases. Some drugs are absorbed at specific site onlythese require release at that specific site. Gastro retentive drug delivery GRDDS is one of the site specific drug delivery for the delivery of the drugs at stomach.
Drug delivery systems DDSs are pharmaceutical formulations or devices that help in achieving targeted delivery andor controlled release CR of therapeutic agents in our body. Following administration the DDSs liberate the active ingredients and subsequently the bioactive molecules are transported across various biological barriers to reach the site of action. Contents of the powerpoint on Evaluation of Oral Controlled drug delivery systems include.
INTRODUCTION ADVANTAGES AND DISADVANTAGES ATTRIBUTES OF DRUG CANDIDATE FOR CONTROLLED RELEASE SYSTEMS INVITRO-INVIVO EVALUATION OF FLOATING DRUG DELIVERY SYSTEM BIOADHESIVE DRUG DELIVERY SYSTEM BUCCAL BIOADHESIVE DRUG DELIVERY SYSTEM COLON SPECIFIC DRUG DELIVERY SYSTEM. A drug delivery system is a formulation or a device that enables the introduction of a therapeutic substance in the body and improves its efficacy and safety by controlling the rate time and place of release of drugs in the body. The increasing interest in sustained release originated the concept of controlled release systems displaying various advantages and disadvantages.
Release delivery systems ml6 nasal and buccal aerosol sprays drug-impregnated lozenges encapsulated cells oral soft gels iontophoretic devices to administer drugs. Targeted Drug Delivery System - An Introduction. Novel carrier systems S P Vyas and R K Khar CBS publishers 2002.
O Progress in Controlled and Novel drug delivery systems by N K Jain CBS publishers 2008. Transdermal Drug Delivery System. Transdermal drug delivery is defined as self contained discrete dosage forms which when applied to the intact skin deliver the drug through the skin at controlled rate to the systemic circulation.
Transdermal drug delivery system TDDS established itself as an integral part of novel drug delivery systems 28. Delivery via the transdermal route is an interesting option. The oral mucosa is an appropriate route for drug delivery systems as it evades first-pass metabolism enhances drug bioavailability and provides the means for rapid drug transport to the systematic circulation.
This delivery system offers a more comfortable and convenient delivery route compared with the intravenous route. An introduction to fast dissolving oral thin film drug delivery systems. Many pharmaceutical companies are switching their products from tablets to fast dissolving oral thin films OTFs.
Films have all the advantages of tablets precise dosage easy administration and those of liquid dosage forms easy swallowing rapid bioavailability. Local delivery to tissues of the oral cavity has a number of applications including treatment of local conditions such as periodontal disease bacterial and fungal infections and aphthous stomatitis and vesiculo bullous diseases. TitleAn Introduction to Fast Dissolving Oral Thin Film Drug Delivery Systems.
6 AuthorsHarsha Kathpalia and Aasavari Gupte AffiliationVivekanand Education Societys College of Pharmacy Hashu Advani Memorial Complex behind Collector Colony Chembur E Mumbai-400 074 India. KeywordsFilm forming polymers Lycoat Monoammonium glycyrrhizinate Oral thin. Oral mucosal drug delivery system is subdivided into buccal and sublingual in which buccal cavity is widely applicable for drug administration through mucosa in case of sublingual route mostly useful for fastest onset of action as in the case of Angina pectoris.
INTRODUCTION At their most basic oral thin films OTFs are polymeric films intended to deliver therapeutic moieties either locally or systemically in the oral cavity or through gastrointestinal absorption. OTFs are an attractive option for drug delivery because of the advantages they offer such as dosing flexibility and ease of administration. Oral drug delivery is by far the most well-known and often the preferred route of drug administration due to its non-invasive nature ease-of-use cost-effectiveness and the highly absorptive properties of the gastrointestinal GI tract.
8 For oral drug delivery to be successful the aqueous solubility of the drug compound in the GI system should be assessed to determine if modifications are. Introduction Amongst the various routes of drug delivery oral route is the most preferred to the patient. However disadvantages such as hepatic first pass metabolism and enzymatic degradation within the GI tract limits its use for certain drugs.